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The no-treatment control may involve a clinical trial design with two or more groups in which one of the groups is not provided treatment. Another form of no-treatment control could involve patients who are on a treatment waiting list, in which they are followed over a period of time; this form of no-treatment control is called a waiting-list control group. A third form could involve a single group in which the subjects are followed for a no-treatment control phase followed by receiving the treatment, called a delayed-treatment control. An example of a delayed-treatment control in a nonrandomized clinical trial involved 20 headache patients, referred to me by a neurology nurse practitioner. The patients completed a headache survey and began their headache duration/intensity, TMD duration/ intensity, and medication intake diaries immediately after they stated their interest in participating in this clinical trial. A few weeks later I evaluated them for the clinical trial, and, if they met the inclusion and exclusion criteria, I made impressions and interocclusal records for stabilization appliances. About 2 weeks later, I inserted the appliances, provided TMD self-management instructions, and asked subjects to again complete the headache survey and to continue their diaries; this provided a delay treatment control phase that averaged a little more than 5 weeks.51 My goal for this clinical trial was to determine clinical predictors so that physicians could identify those headache patients who would most bene t from TMD selfmanagement instructions and a stabilization appliance. The subjects had great variations in the degree of headache improvement obtained, but no clear clinical predictors emerged to identify those headache patients who would bene t most from these therapies. An interesting caveat that did emerge was that patients with tension-type, migraine without aura, and migraine with aura headaches

Late October 1997 seemed to represent the culmination of the crisis that had hit rst with the devaluation of the Thai baht in July and then spread to weaken Asian currencies and markets generally On October 27, heavy selling in Hong Kong spooked the US equity market, which dropped about 7% Markets around the world followed suit Increased equity market volatility pushed up demand for options In Europe, implied volatility rose to 24%, well above the historical level of 15% LTCM viewed this as a ripe pro t opportunity Through the end of 1997 and into 1998, it sold large amounts of long-dated option positions on US and European equity indexes This seemed like a good bet at rst, as equity markets recovered strongly after October 1997.

5

Run-Time Monitoring and Failure Detection Analyzing the large number of sequences exercised during reachability testing must be automated at least partially In 3 we described techniques for detecting data races and deadlocks automatically Since reachability testing provides some guarantees about the completeness of testing, it can be used to bridge the gap between testing and veri cation Run-time veri cation techniques are needed for specifying and verifying correctness properties against the individual sequences generated during reachability testing Formal Methods and Model Checking There is growing interest in combining formal methods and testing Some formal methods are model based, which means that a nite-state model must be extracted from a program before the program can be veri ed Static analysis methods for model extraction have dif culty handling dynamic objects such as threads, heaps, and data structures These objects ought to be easier to handle in a dynamic framework.

Long-term government bond yields, especially in the United States, also continued to narrow, as did the spread between corporates and government bonds From beneath this seemingly benign surface, however, problems began to emerge in early 1998 In particular, investors in mortgage-backed securities suffered a sharp setback when lowered interest rates sparked an unexpectedly heavy rush of prepayments Some covered their losses by selling off pro table positions in emerging market debt These sales, however, seemed to awaken investors perception of risk in emerging markets Money was pulled out of these markets, driving prices down, and reinvested in developed countries government securities, raising prices in those markets As a result, interest rate swap spreads widened LTCM ended May down about 65% and June down another 10% It was the rst time in its history that the rm had experienced losses in two consecutive months.

LTCM decided to respond by lowering its risk The daily standard deviation of the rm s portfolio amounted to about $45 million, in line with the its objective of targeting the volatility of the.

*All data through June 2003. Manager tenure stated in years and represents period managing current product.